Scientific PEMF Studies

Many PEMF scientific studies on the success and efficacy of Pulsed Electro Magnetic Field therapy are available in the public domain. 


Disturbances in circulation of blood and metabolism play a very important role in development of diseases.


Therapy with pulsed electro magnetic fields energy is based on more than 40 years of clinical research done by renowned scientists. There are also decades of practical experience by numerous medical doctors and therapists.

PEMF Scientific Studies

This review will attempt to give the reader an introduction and assessment of EMF modalities which have demonstrated therapeutic benefit for bone and wound repair and chronic and acute pain relief. This review will concentrate on the use of exogenous time-varying and static magnetic fields.

Electromagnetic fields are widely used in therapeutic medical applications. Proof of effectiveness has been demonstrated in numerous clinical applications of low-intensity ELF-EMF and RF-EMF, each treatment employing specific characteristics of frequency, modulation and intensity to achieve its efficacy.

This review explores the value of magnetic therapy in rehabilitation medicine in terms of static magnetic fields and time varying magnetic fields (electromagnetic). A historical review is given and the discussion covers the areas of scientific criteria, modalities of magnetic therapy, mechanism of the biologic effects of magnetic fields, and perspectives on the future of magnetic therapy.

Pulsed electromagnetic fields (PEMFs) have a number of well-documented physiological effects on cells and tissues including the upregulation of gene expression of members of the transforming growth factor b super family, the increase in glycosaminoglycan levels, and an antiinflammatory action. Therefore, there is a strong rationale supporting the in vivo use of biophysical stimulation with PEMFs for the treatment of OA. In the present paper some recent experimental in vitro and in vivo data on the effect of PEMFs on articular cartilage were reviewed. These data strongly support the clinical use of PEMFs in OA patients.

This study examines the effect of treatment with a pulsed electromagnetic field (PEMF) upon the morphological progression of osteoarthritis in this animal model. Treatment with PEMF appears to be disease-modifying in this model of osteoarthritis. Since TGFβ is believed to upregulate gene expression for aggrecan, downregulate matrix metalloprotease and IL-1 activity, and upregulate inhibitors of matrix metalloprotease, the stimulation of TGFβ may be a mechanism through which PEMF favorably affects cartilage homeostasis.

The results of this study show the range of exposure length, PEMF amplitude, pulse frequency which can stimulate cartilage PG synthesis, and suggest optimal exposure parameters which may be useful for cartilage repair in in vivo experiments and clinical application.

What's this item about? What makes it interesting? Write a catchy description to grab your audience's attention...Osteo-arthritis, a painful joint disorder involving degenerative changes of the articular cartilage and subchondral bone, often results in progressive functional impairment and disability. One particular modality used by physiotherapists that shows very promising results in reducing the joint damage and pain found in osteo-arthritis is pulsed electromagnetic fields. The basic and clinical research in this field, while somewhat limited, supports the insightful application of pulsed electromagnetic fields to ameliorate pain and disability due to osteo-arthritis.


  • Prevention of osteoporosis by pulsed electromagnetic fields.

  • Modification of osteoarthritis by pulsed electromagnetic field

  • Bone density changes in osteoporosis-prone women exposed to pulsed electromagnetic fields (PEMFs).

  • Electromagnetic fields for bone healing.

  • The effect of low-frequency electrical fields on osteogenesis.

  • Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs).

Osteoporosis is becoming a great social and medical problem due to the elderly population. Various forms of prevention and treatment are needed to deal with this problem. It has been found that pulsed electromagnetic field therapy is safe and effective in treating osteoporosis. This review thus concentrates on the progress of recent studies done so far on PEMF in the treatment of osteoporosis.

We have concluded that there is an effective window of pulsed electromagnetic fields in which bone mass can be controlled in the absence of function.

We have shown that these electrical fields can slow, inhibit, or even reverse the osteoporotic processes that normally accompany disuse in our animal model.

Abstracts- Effects of pulsed electromagnetic fields in Steinberg ratings of femoral head osteonecrosis.

This study aimed to determine the efficacy of PEMF (pulsed electromagnetic field) treatment in experimental osteochondral defect healing in a rabbit model.

The effect of PEMF on bone metabolism in experimental disuse osteoporosis

The aim of this study was to determine the influence of PEMFs on nucleus pulposus (NP) cell proliferation and the synthesis of disc-specific proteins.

Abstracts- Therapeutic effects of pulsed magnetic fields on joint diseases.

This study demonstrates that pulsed electromagnetic fields are able to accelerate wound healing under diabetic and normal conditions by up-regulation of FGF-2-mediated angiogenesis. They also prevented tissue necrosis in response to a standardized ischemic insult, suggesting that noninvasive angiogenic stimulation by pulsed electromagnetic fields may be useful to prevent ulcer formation, necrosis, and amputation in diabetic patients.

The results suggest a significant beneficial stimulation in the wound healing process in rats treated with PEMF, which could lead to the development of a practical tool for research and clinical use.

Despite the small numbers in this pilot study, electromagnetic therapy provided significant gains in the healing of venous leg ulcers and reduction in pain.

Effects of low frequency PEMF on skin ulcers of venous origin in humans: A double blind study

Electromagnetic stimulation as a treatment of tinnitus

We aimed to investigate the efficacy of pulsed electromagnetic field (PEMF) in lateral epicondylitis comparing the modality with sham PEMF and local steroid injection.

PEMF seems to reduce pain better than sham PEMF and may be a helpful modality in the treatment of lateral epicondylitis. Although the treatment time is quite long and necessitate compliance, it can be used in patients avoiding invasive approaches. Corticosteroid and anesthetic agent injections can be used in patients for rapid return to activities.

PEMF therapy has been used successfully in the management of postsurgical pain and edema, the treatment of chronic wounds, and in facilitating vasodilatation and angiogenesis. Using scientific support, the authors present the currently accepted mechanism of action of PEMF therapy.

This review shows that plastic surgeons have at hand a powerful tool with no known side effects for the adjunctive, noninvasive, nonpharmacologic management of postoperative pain and edema. Given the recent rapid advances in development of portable and economical PEMF devices, what has been of most significance to the plastic surgeon is the laboratory and clinical confirmation of decreased pain and swelling following injury or surgery.

William Pawluk, MD, MSc

Research has shown that PEMFs produce a number of anti-stress changes in the body, both to ward off stress, that is, create stress resistance, and to decrease the hormonal, immune, neurologic, soft tissue, cardiac, vascular, low pH and low-oxygen damage caused by stress. From this perspective, very low-level PEMFs used regularly should be able to prevent or reverse many of the effects of stress that all of us experience daily.

Ivan L. Cameron, Nicholas J. Short, Marko S. Markov

This article highlights recent research on the beneficial use of selected low frequency electromagnetic fields (EMF) as a safe alternative therapy for treatment of cancer and other health problems. It is shown that EMF therapy provides a safe alternative and adjunct modality for the treatment of cancer and other health problems, and therefore, research in this field deserves more support. The paper also discusses some reports and hypothesis of potential risk of human exposure to low frequency EMF, mainly to the power line frequency of 60 Hz.

In-depth Studies have been performed into Multiple Sclerosis, providing indications which support the therapeutic use of Pulsing Electromagnetic Field Therapy across many elements of the disease.

Abstracts on the effectiveness of electrical stimulation and Pulsed Electro Magnetic Field (PEMF) stimulation for promoting bone and fracture healing.

Abstracts- PEMF for preserving bone mass, fracture healing, fibular osteotomies healing.

The impact of treatment with magnetic fields on a variety of physical ailments are presented in the following descriptions of recent studies, published in peerreviewed scientific journals.

A wealth of articles on Pulsing Electromagnetic Field therapy (PEMF) technology is available. Following is a selection of abstracts, articles and references on PEMF. This information has been collected to indicate the benefits on the use of pulsing electromagnetic field therapy and many are double blind, placebo controlled studies.  

PEMF applications

A biphasic dose response has been frequently observed where low levels of light have a much better effect on stimulating and repairing tissues than higher levels of light. The so-called Arndt-Schulz curve is frequently used to describe this biphasic dose response. This review will cover the molecular and cellular mechanisms in LLLT, and describe some of our recent results in vitro and in vivo that provide scientific explanations for this biphasic dose response.

Transmission electron microscopic images have demonstrated the formation of transitory pores in adipocyte cell membranes followed by the collapse of adipose cells subsequent to laser irradiation of 635 nm. The objective is to evaluate the application of a 635nm and 17.5mWexit power per multiple diode laser for the application of non-invasive body contouring of the waist, hips, and thighs.

These data suggest that low-level laser therapy can reduce overall circumference measurements of specifically treated regions.

Noninvasive body contouring has become a popular solution to deal with unwanted fat. LLLT has previously been used for a wide variety of medical conditions that include wound healing, reduction of edema, and pain relief. Within the past decade, it has become the newest modality for noninvasive body contouring, treating a patient population that is shying away from surgical cosmetic procedures and opting for lessinvasive and safer options. Research has demonstrated that LLLT can reduce overall body circumference measurements of specifically treated as well as nontreated remote regions. It has been proven effective, and cleared by the FDA for the reduction of circumference of hips, waist, thighs, and, most recently, upper arms. Recent studies indicate that the results of LLLT are long-lasting if not permanent. With no adverse events reported to date, LLLT appears to be both safe and effective for fat reduction and body slimming.

Low level light/laser therapy (LLLT) is the direct application of light to stimulate cell responses (photobiomodulation) in order to promote tissue healing, reduce inflammation and induce analgesia. There have been significant studies demonstrating its application and efficacy at many sites within the body and for treatment of a range of musculoskeletal injuries, degenerative diseases and dysfunction, however, its use on oral tissues has, to date, been limited. The purpose of this review is to consider the potential for LLLT in dental and oral applications by providing background information on its mechanism of action and delivery parameters and by drawing parallels with its treatment use in analogous cells and tissues from other sites of the body.

A literature search on Medline was performed on laser and light treatments in a range of dental/orofacial applications from 2010 to March 2013. The search results were filtered for LLLT relevance. The clinical papers were then arranged to eight broad dental/orofacial categories and reviewed.
Results. The initial search returned 2778 results, when filtered this was reduced to 153. 41 were review papers or editorials, 65 clinical and 47 laboratory studies. Of all the publications, 130 reported a positive effect in terms of pain relief, fast healing or other improvement in symptoms or appearance and 23 reported inconclusive or negative outcomes. Direct application of light as a therapeutic intervention within the oral cavity (rather than photodynamic therapies, which utilize photosensitizing solutions) has thus far received minimal attention. Data from the limited studies that have been performed which relate to the oral cavity indicate that LLLT may be a reliable, safe and novel approach to treating a range of oral and dental disorders and in particular for those which there is an unmet clinical need.

LLLT for hair growth in both men and women appears to be both safe and effective. The optimum wavelength, coherence and dosimetric parameters remain to be determined.

LLLT was discovered serendipitously in the 1960s when mice irradiated with a low fluence red laser grew hair. Since that time LLLT has demonstrated promise in conditions from wound healing to stroke recovery, from treatment of musculoskeletal pain to prevention of mucositis. Animal and human data have slowly accumulated supporting LLLT for hair growth (Table 1). LLLT appears to improve a variety of non-scarring alopecias—AGA, AA, and chemotherapy-induced alopecia. Based on the studies demonstrating LLLT's effects on promoting graft survival, it may be further suggested to have a potential to be used during the immediate period of post-hair transplant surgery to facilitate the healing process and enhance viability and earlier growth of the grafts [60,61]. While mechanisms are still emerging, LLLT may increase anagen hairs through release of NO from CCO by photodissociation and LLLT may reduce inflammation in AA. However, more studies are needed to optimize treatment parameters and determine long-term efficacy as well as safety of emerging LLLT technologies. Most studies investigating effects of LLLT on hair growth have used wavelengths that range from 635 to 650 nm, but as of today no study has compared the effect of near-infrared wavelengths such as 810 nm, which have deeper penetrating capacities, to red light. Moreover, further studies are required to compare efficacy of different light sources (continuous vs. pulsed) and methods of light delivery (laser vs. LED).

The present study demonstrates that that low level laser (light) treatment of the scalp every other day for 16 weeks using the TOPHAT 655 device is a safe and effective treatment for androgenic alopecia in healthy women between the ages of 18–60 with Fitzpatrick Skin Types I–IV and Ludwig–Savin Baldness Scale I-2–II-2 baldness patterns. Subjects receiving LLLT at 655nm achieved a 37% increase in hair counts as compared to sham treated control patients in this multicenter RCT. These results are similar to those reported in an earlier study using the same device in males with alopecia.

Forty-two patients completed the study (24 active, 18 sham). No adverse events or side effects were reported. Baseline hair counts were 228.2133.4 (N¼18) in the sham and 209.6118.5 (N¼24) in the active group (P¼0.642). Post Treatment hair counts were 252.1143.3 (N¼18) in the sham group and 309.9 166.6 (N¼24) in the active group (P¼0.235). The change in hair counts over baseline was 23.930.1 (N¼18) in the sham group and 100.353.4 (N¼24) in the active group (P<0.0001). The percent hair increase over the duration of the study was 11.0548.30 (N¼18) for the sham group and 48.0717.61 (N¼24) for the active group (P<0.001).
This demonstrates a 37% increase in hair growth in the active treatment group as compared to the placebo group.
Conclusions: LLLT of the scalp at 655nm significantly improved hair counts in women with androgenetic alopecia at a rate similar to that observed in males using the same parameters.

Low level laser therapy is effective at significantly decreasing postoperative pain and the amount of pain medication needed after breast augmentation at 1 day and 1 week respectfully. All other covariants studied including, implant type, implant size, incision size, implant location, test site location, amount of swelling measurements, hydration level, and adverse events were found to be neglible.

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